Disulfiram (DEDTC Metabolite), Blood Test (1790B)
| Analysis Code |
1790B |
| Test Name |
Disulfiram (DEDTC Metabolite), Blood |
| Test Includes |
Diethyldithiocarbamate [GC] |
| Compound Synonym(s) |
Antabuse
DEDTC
Diethyldithiocarbamate
Disulfiram Metabolite |
| Purpose |
Therapeutic Drug Monitoring; Compliance Monitoring |
| Category |
Alcohol Deterrent |
| Method(s) |
Gas Chromatography (GC) |
| Specimen Requirements |
7 mL Blood |
| Transport Temperature |
Frozen |
| Specimen Container |
Lavender top tube (EDTA) |
| Special Handling |
None |
| Light Protection Required |
Not Required |
| Stability |
Room Temperature: Undetermined
Refrigerated: Undetermined
Frozen (-20 °C): Undetermined
Disulfiram is rapidly and completely reduced to diethyldithiocarbamate (DEDTC) in blood within 4 minutes of addition to human blood or plasma. DEDTC, an excellent chelator of numerous metal ions, has an in vitro half-life of approximately 70 minutes in either human blood or plasma at room temperature, but nonenzymatically degraded (especially in an acid medium) to carbon disulfide and diethylamine.
It is required that specimens be frozen within one hour of drawing blood or urine. In the event that specimens are not frozen within this timeframe the utility of the test is compromised. |
| Rejection Criteria |
Glass container. |
| Day(s) Test Set-up |
[GC] Sunday 4 days |
| Suggested CPT Code |
[GC] 82491 |
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