Disulfiram (DEDTC Metabolite), Serum/Plasma Test (1790SP)
| Analysis Code |
1790SP |
| Test Name |
Disulfiram (DEDTC Metabolite), Serum/Plasma |
| Test Includes |
Diethyldithiocarbamate [GC] |
| Compound Synonym(s) |
Antabuse
DEDTC
Diethyldithiocarbamate
Disulfiram Metabolite |
| Purpose |
Therapeutic Drug Monitoring; Compliance Monitoring |
| Category |
Alcohol Deterrent |
| Method(s) |
Gas Chromatography (GC) |
| Specimen Requirements |
7 mL Serum or Plasma |
| Transport Temperature |
Frozen |
| Specimen Container |
Lavender top tube (EDTA) |
| Special Handling |
Promptly centrifuge and separate Serum or Plasma into a plastic screw capped vial using approved guidelines. |
| Light Protection Required |
Not Required |
| Stability |
Room Temperature: Undetermined
Refrigerated: Undetermined
Frozen (-20 °C): Undetermined
Disulfiram is rapidly and completely reduced to diethyldithiocarbamate (DEDTC) in blood within 4 minutes of addition to human blood or plasma. DEDTC, an excellent chelator of numerous metal ions, has an in vitro half-life of approximately 70 minutes in either human blood or plasma at room temperature, but nonenzymatically degraded (especially in an acid medium) to carbon disulfide and diethylamine.
It is required that specimens be frozen within one hour of drawing blood or urine. In the event that specimens are not frozen within this timeframe the utility of the test is compromised. |
| Rejection Criteria |
Glass container. Polymer gel separation tube (SST or PST). |
| Day(s) Test Set-up |
[GC] Sunday 4 days |
| Suggested CPT Code |
[GC] 82491 |
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