Designer Opioids (2018 Scope), Blood

Test Summary Sheet for:

Purpose

Identification and Quantitation

Method(s)

High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)

Suggested CPT Code(s)

80364

New York State Approval Status

Approved

Known Interference(s)

Cyclopropylfentanyl [LC-MS/MS]: Crotonylfentanyl impurity

Isobutyrylfentanyl [LC-MS/MS]: beta-methylfentanyl

ortho-Fluorofentanyl [LC-MS/MS]: Ortho-fluorobutyrylfentanyl impurity

para-Fluorobutyrylfentanyl [LC-MS/MS]: meta-Fluorobutyrylfentanyl

para-Fluorofentanyl [LC-MS/MS]: Meta-fluorofentanyl

trans-3-Methylfentanyl [LC-MS/MS]: Crotonylfentanyl

Turnaround Time

5 days

Test Includes


1	Methoxyacetylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
2	4-ANPP	Despropionyl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.1	NPS
3	THF-F	Tetrahydrofuran fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
4	meta-Methylmethoxyacetylfentanyl	3-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
5	para-Methylmethoxyacetylfentanyl	4-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
6	Acryl Fentanyl	Acryloylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
7	para-Fluorofentanyl	4-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Meta-fluorofentanyl
8	ortho-Fluorofentanyl	2-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Ortho-fluorobutyrylfentanyl impurity
9	2-Furanylfentanyl	Fu-F; Furanylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
10	U-47700	U-4	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
11	U-49900		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
12	U-51754		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
13	Carfentanil	Carfentanyl; Wildnil®	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
14	Cyclopropylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonylfentanyl impurity
15	trans-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonylfentanyl
16	cis-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
17	Isobutyrylfentanyl	Isobutyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	beta-methylfentanyl
18	Butyrylfentanyl	Butyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
19	para-Fluoroisobutyrylfentanyl	4F-Isobutyrylfentanyl; FIBF	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
20	para-Fluorobutyrylfentanyl	4F-butyryl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	meta-Fluorobutyrylfentanyl
21	Valeryl Fentanyl	Pentylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS

Specimen Type

Blood

Requested Volume

2 mL

Minimum Volume

0.7 mL

Special Handling

None

Specimen Container

Gray top tube (Sodium Fluoride / Potassium Oxalate)

Additional Collection Instructions

Transport Temperature

Frozen

Light Protection

Not Required

Rejection Criteria

Received Room Temperature. Received Refrigerated.

Rejection criteria pertain to clinical specimen submissions only.

Stability

Room Temperature: Not Stable
Refrigerated: 2 day(s)
Frozen (-20 °C): 14 day(s)


1	Methoxyacetylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
2	4-ANPP	Despropionyl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.1	NPS
3	THF-F	Tetrahydrofuran fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
4	meta-Methylmethoxyacetylfentanyl	3-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
5	para-Methylmethoxyacetylfentanyl	4-Methylmethoxyacetylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
6	Acryl Fentanyl	Acryloylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
7	para-Fluorofentanyl	4-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Meta-fluorofentanyl
8	ortho-Fluorofentanyl	2-Fluorofentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Ortho-fluorobutyrylfentanyl impurity
9	2-Furanylfentanyl	Fu-F; Furanylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
10	U-47700	U-4	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
11	U-49900		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
12	U-51754		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
13	Carfentanil	Carfentanyl; Wildnil®	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
14	Cyclopropylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonylfentanyl impurity
15	trans-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	Crotonylfentanyl
16	cis-3-Methylfentanyl		High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
17	Isobutyrylfentanyl	Isobutyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	beta-methylfentanyl
18	Butyrylfentanyl	Butyrfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
19	para-Fluoroisobutyrylfentanyl	4F-Isobutyrylfentanyl; FIBF	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS
20	para-Fluorobutyrylfentanyl	4F-butyryl fentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS	meta-Fluorobutyrylfentanyl
21	Valeryl Fentanyl	Pentylfentanyl	High Performance Liquid Chromatography/ Tandem Mass Spectrometry (LC-MS/MS)	ng/mL	0.05	NPS

Example Report (Negative)

Example Report (Positive)

Interface Map

1480B Designer Opioids (2018 Scope), Blood - Current Version
Analyte	Units	Analyte Mapping Code
Methoxyacetylfentanyl	ng/mL	MXYACFEN
4-ANPP	ng/mL	4ANPP
THF-F	ng/mL	THFF
meta-Methylmethoxyacetylfentanyl	ng/mL	MMMAFENT
para-Methylmethoxyacetylfentanyl	ng/mL	PMMAFENT
Acryl Fentanyl	ng/mL	ACRYLFEN
para-Fluorofentanyl	ng/mL	PFLFENT
ortho-Fluorofentanyl	ng/mL	OFLFENT
2-Furanylfentanyl	ng/mL	2FURANF
U-47700	ng/mL	U47700
U-49900	ng/mL	U49900
U-51754	ng/mL	U51754
Carfentanil	ng/mL	CARFENTANI
Cyclopropylfentanyl	ng/mL	CYCLOFEN
trans-3-Methylfentanyl	ng/mL	3TRANMFENT
cis-3-Methylfentanyl	ng/mL	3CISMFENT
Isobutyrylfentanyl	ng/mL	IBUTYRF
Butyrylfentanyl	ng/mL	BUTYRFEN
para-Fluoroisobutyrylfentanyl	ng/mL	FIBF1
para-Fluorobutyrylfentanyl	ng/mL	PFBF
Valeryl Fentanyl	ng/mL	VALFENT

LOINC^® Information

1480B Designer Opioids (2018 Scope), Blood - Current Version
Analyte	Units	Analyte Mapping Code
Methoxyacetylfentanyl	ng/mL	MXYACFEN
4-ANPP	ng/mL	4ANPP
THF-F	ng/mL	THFF
meta-Methylmethoxyacetylfentanyl	ng/mL	MMMAFENT
para-Methylmethoxyacetylfentanyl	ng/mL	PMMAFENT
Acryl Fentanyl	ng/mL	ACRYLFEN
para-Fluorofentanyl	ng/mL	PFLFENT
ortho-Fluorofentanyl	ng/mL	OFLFENT
2-Furanylfentanyl	ng/mL	2FURANF
U-47700	ng/mL	U47700
U-49900	ng/mL	U49900
U-51754	ng/mL	U51754
Carfentanil	ng/mL	CARFENTANI
Cyclopropylfentanyl	ng/mL	CYCLOFEN
trans-3-Methylfentanyl	ng/mL	3TRANMFENT
cis-3-Methylfentanyl	ng/mL	3CISMFENT
Isobutyrylfentanyl	ng/mL	IBUTYRF
Butyrylfentanyl	ng/mL	BUTYRFEN
para-Fluoroisobutyrylfentanyl	ng/mL	FIBF1
para-Fluorobutyrylfentanyl	ng/mL	PFBF
Valeryl Fentanyl	ng/mL	VALFENT


Some LOINC^® codes may not have been assigned or are not available. The LOINC^® codes are copyright © 1995-2017, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. All rights reserved. Additional information can be found at LOINC.org.

The CPT Codes provided in this document are based on AMA Guidelines and are for informational purposes only. NMS Labs Does not assume responsibility for billing errors due to Reliance on the CPT Codes listed in this document.

*The information contained in this document represents database configurations, as they will appear on the effective date listed above.